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Principal Investigator
Ling Xiang
The Second Affiliated Hospital of Chongqing Medical University
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Jan 23, 2023
Association between low-fat dairy consumption and risk of lung cancer in the PLCO Cancer Screening Trial
According to the Global Cancer Statistics, lung cancer is the second most common malignancy after female breast cancer, with approximately 2.2 million new diagnosed cases in 2020, accounting for 11.4% of all cancers(1). The association of dairy consumption with a variety of cancers has been investigated. However, there are only a few studies on lung cancer and the results are controversial(2-4). Previous evidence suggested that the relationship between dairy products and cancers may vary depending on the fat content and types of dairy products(5). Therefore, we speculate that the inconsistent findings for lung cancer may result from differences in dairy products. In recent years, low-fat dairy products have replaced whole-fat dairy products in the main dietary guidelines due to their more beneficial effects on human health(6). However, the relationship between low-fat dairy consumption and lung cancer risk is unclear. we performed this study to investigate this relationship.

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3):209-49.
2. Yang JJ, Yu D, Xiang YB, Blot W, White E, Robien K, et al. Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk: A Pooled Analysis. JAMA oncology. 2020;6(2):e194107.
3. Lumsden AL, Mulugeta A, Hyppönen E. Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study. Clinical nutrition (Edinburgh, Scotland). 2023;42(1):1-8.
4. Hosseini M, Naghan PA, Jafari AM, Yousefifard M, Taslimi S, Khodadad K, et al. Nutrition and lung cancer: a case control study in Iran. BMC cancer. 2014;14:860.
5. Park SY, Murphy SP, Wilkens LR, Stram DO, Henderson BE, Kolonel LN. Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. American journal of epidemiology. 2007;166(11):1259-69.
6. Yakoob MY, Shi P, Willett WC, Rexrode KM, Campos H, Orav EJ, et al. Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two Large Prospective Cohorts. Circulation. 2016;133(17):1645-54.

To investigate whether low-fat dairy consumption is associated with lung cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.


Yaxu Wang, Linglong Peng, Haitao Gu, Zhiquan Xu, Hongmei He.
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China