Reexamine trial outcomes in PLCO to identify interactions of screening effects with screen results and other covariates

Principal Investigator

Name
Hormuzd Katki

Degrees
PhD

Institution
NCI

Position Title
Senior Investigator

Email
katkih@mail.nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-1091

Initial CDAS Request Approval
Nov 1, 2022

Title
Reexamine trial outcomes in PLCO to identify interactions of screening effects with screen results and other covariates

Summary
Reexamine trial outcomes (mortality and late-stage cancer incidence) for each of the P L C and O cancers over time by screen results and covariates

Aims

* Recalculate survival curves for each P L C and O trial outcomes to compare cancer mortality versus late-stage stage cancer incidence
* Estimate survival curves by screening results and covariates to examine interactions of arm by screening result and covariates

Collaborators

Ping Hu (NCI)
Paul Pinsky (NCI)

Related Publications

• Data-integration with pseudoweights and survey-calibration: application to developing US-representative lung cancer risk models for use in screening.
  Wang L, Li Y, Graubard BI, Katki HA
  J R Stat Soc Ser A Stat Soc. 2025 Jan; Volume 188 (Issue 1): Pages 119-139 PUBMED