Study
PLCO
(Learn more about this study)
Project ID
PLCO-1078
Initial CDAS Request Approval
Oct 19, 2022
Title
Alcohol Intake Across the Life Course and Risk of Ovarian Cancer in Postmenopausal Women
Summary
Ovarian cancer is the second most common gynecological cancer in the United States and one of the deadliest cancers of the female reproductive system. Epidemiologic evidence suggests that longer exposure to estrogen may contribute to ovarian carcinogenesis. Higher estrogen levels associated with alcohol use and its linkage to breast cancer is well established. However, the association between alcohol consumption and risk of ovarian cancer remains unclear. This study aims to investigate the relationship between patterns of lifetime alcohol exposure and ovarian cancer risk. Utilizing data on female participants from both arms of the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial, lifetime alcohol consumption, alcohol consumption at each age group, and lifetime alcohol consumption by source (beer, wine, and liquor) will be calculated using Diet History Questionnaire (DHX) data. Additionally, differences in the various types of ovarian cancers in the context of alcohol exposure among women will be assessed.
Aims
• Estimate incidence of ovarian cancer among female PLCO participants and identify potential risk and protective factors.
• Estimate risk between lifetime alcohol consumption and risk for ovarian cancer, overall and by type (Invasive Ovarian, Primary Peritoneal, Fallopian Tube, Ovarian Low Malignancy Potential Tumor, Peritoneal Low Malignancy Potential Tumor, Fallopian Tube Low Malignancy Potential Tumor).
• Examine differences in overall ovarian cancer risk by quantity (light, moderate, heavy) and type (beer, wine, liquor) of alcohol consumed.
• Evaluate the association between alcohol consumption at various ages and overall ovarian cancer risk.
Collaborators
Alexandra Schmidt, B.B.A., University of North Dakota
Corey B. Smith, Ph.D., University of North Dakota
