Skip to Main Content
Principal Investigator
Kara Michels
Albert Einstein College of Medicine
Position Title
Assistant Professor
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Feb 1, 2023
Infection and immunity in uterine corpus and ovarian cancers
Although risk factors for uterine corpus and ovarian cancers have been identified, many of these factors are common (e.g., obesity)–they can't be used to identify the women at greatest risk for these diseases, nor can they be intervened on (e.g., age). These risk factors are also not strongly associated with the most aggressive histotypes of uterine corpus and ovarian cancers. Our study will explore the potential role of infections in the etiology of these cancers. Such infections are treatable, and knowledge about prior infections could someday be used as a screening tool for cancer risk. We will first replicate associations between these cancers and a set of novel circulating biomarkers that provide information on prior infectious exposures. Secondly, we will use tumor tissue samples to examine several relevant immunohistochemistry markers and also make comparisons by histotype. This research will help us understand if and potentially how, certain infections increase risk for subtypes of uterine corpus and ovarian cancers.

1. To replicate previously identified associations between seropositivity to select microbial antigens and risks for uterine and ovarian cancers, by histotype.

2. To quantify and describe patterns of immune cell infiltration across uterine and ovarian cancers, by histotype.


Kara Michels (Albert Einstein College of Medicine)
Britton Trabert (Huntsman Cancer Institute, University of Utah)