Sharing PLCO oncoarray genotyping and covariate data with the African Ancestry Breast Cancer Consortium
Principal Investigator
Name
Thomas Ahearn
Degrees
PhD, MPH
Institution
Division of Cancer Genetics and Epidemiology, NCI
Position Title
Staff Scientisst
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1001
Initial CDAS Request Approval
Jul 1, 2022
Title
Sharing PLCO oncoarray genotyping and covariate data with the African Ancestry Breast Cancer Consortium
Summary
Vanderbilt University Medical Center is the coordinating center for the African Ancestry Breast Cancer Consortium (AABCG, PI: Dr. Wei Zheng, ). The objective of the AABCG is to identify low-penetrance genetic variants associated with breast cancer risk in women of African descent and involves the collection of data from tens of thousands of samples collected from breast cancer patients and control subjects of African descent to identify genetic risk factors for breast cancer.
PLCO does not have adequate sample size to investigate the etiology of breast cancer in women of African ancestry, thus we would like to contribute data from African ancestry participants in PLCO to the AABCG, which will harmonize data from multiple studies to study breast cancer in women of African ancestry.
PLCO genetic and phenotype data shared with AABCG will be will be re-shared by AABCG/VUMC for additional studies that are approved by the AABCG data access coordinating committee (DACC). PLCO will be given the opportunity to choose to opt-in/out of studies that are approved by the AABCG DACC.
PLCO does not have adequate sample size to investigate the etiology of breast cancer in women of African ancestry, thus we would like to contribute data from African ancestry participants in PLCO to the AABCG, which will harmonize data from multiple studies to study breast cancer in women of African ancestry.
PLCO genetic and phenotype data shared with AABCG will be will be re-shared by AABCG/VUMC for additional studies that are approved by the AABCG data access coordinating committee (DACC). PLCO will be given the opportunity to choose to opt-in/out of studies that are approved by the AABCG DACC.
Aims
1) To investigate breast cancer genetics in African Ancestry populations to better understand the genetic architecture of the disease.
2) To investigate the role of non-genetic risk factors in breast cancer etiology, prognosis, and survival in African Ancestry populations
Collaborators
Montserrat Garcia-Closas, DCEG/NCI
Wei Zheng, Vanderbilt University Medical Center
Related Publications
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Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.
Jia G, Ping J, Guo X, Yang Y, Tao R, Li B, Ambs S, Barnard ME, Chen Y, Garcia-Closas M, Gu J, Hu JJ, Huo D, John EM, Li CI, Li JL, Nathanson KL, Nemesure B, Olopade OI, Pal T, ...show more Press MF, Sanderson M, Sandler DP, Shu XO, Troester MA, Yao S, Adejumo PO, Ahearn T, Brewster AM, Hennis AJM, Makumbi T, Ndom P, O'Brien KM, Olshan AF, Oluwasanu MM, Reid S, Butler EN, Huang M, Ntekim A, Qian H, Zhang H, Ambrosone CB, Cai Q, Long J, Palmer JR, Haiman CA, Zheng W
Nat Genet. 2024 May 13 PUBMED