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Ultra-processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

Principal Investigator
Name
Guo-Chao Zhong
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Director of the department
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-940
Initial CDAS Request Approval
Mar 22, 2022
Title
Ultra-processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Summary
Pancreatic cancer is the fourth leading cause of cancer-related mortality in the US population, and its prognosis is still dismal. Hence, identifying modifiable risk factors is important for decreasing the burden of this disease. The well-established risk factors for pancreatic cancer include type 2 diabetes, cigarette smoking, and obesity (1). Interestingly, dietary habits have been also indicated to play an important role in the initiation and development pancreatic cancer (2).
Ultra-processed food consumption has been associated with a series of health outcomes, including metabolic syndrome and type 2 diabetes. However, to our knowledge, no prospective cohort study has accurately evaluated the potential association between ultra-processed food consumption and the risk of pancreatic cancer. Hence, we sought to examine this potential association in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

References:
1. Tsai HJ, Chang JS. Environmental Risk Factors of Pancreatic Cancer. J Clin Med. 2019;8(9).
2. Casari I, Falasca M. Diet and Pancreatic Cancer Prevention. Cancers (Basel). 2015;7(4):2309-17.
Aims

To examine the potential association between ultra-processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Collaborators

(1) Qian Zhu, Department of Epidemiology and Biostatistics, School of Public Health and Management, Chongqing Medical University, Chongqing, China ;
(2) Wei-Ping Sun, Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

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