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Iron homeostasis and colorectal adenoma risk in the Prostate, Lung, Colorectal & Ovarian (PLCO) Cancer Screening Trial

Principal Investigator

Name
Amanda Cross

Degrees
-

Institution
NCI, DCEG, NEB

Position Title
-

Email
crossa@mail.nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
2005-0012

Initial CDAS Request Approval
Aug 17, 2005

Title
Iron homeostasis and colorectal adenoma risk in the Prostate, Lung, Colorectal & Ovarian (PLCO) Cancer Screening Trial

Summary
We hypothesize that increased exposure to iron is a risk factor for colorectal cancer. Therefore, the aims of this study are to investigate whether increased iron exposure is associated with colorectal adenoma, an established precursor of colorectal cancer, in a case-control study nested within a large randomized controlled trial. We specifically plan to investigate: Dietary iron intake, using a novel iron database, in relation to advanced colorectal adenoma risk. The association between body iron status, as bound and free iron, and risk of advanced colorectal adenoma. Polymorphic variation of iron homeostatic genes in relation to iron exposure & advanced colorectal adenoma risk.

Aims

We hypothesize that increased exposure to iron is a risk factor for colorectal cancer. Therefore, the aims of this study are to investigate whether increased iron exposure is associated with colorectal adenoma, an established precursor of colorectal cancer, in a case-control study nested within a large randomized controlled trial. We specifically plan to investigate: Dietary iron intake, using a novel iron database, in relation to advanced colorectal adenoma risk. The association between body iron status, as bound and free iron, and risk of advanced colorectal adenoma. Polymorphic variation of iron homeostatic genes in relation to iron exposure & advanced colorectal adenoma risk.

Collaborators

Stephen Chanock (CGF, NCI)
Amanda Cross (NCI, DCEG)
Marc Gunter (NCI, DCEG)
Richard Hayes (NCI, DCEG)
Martin Kulldorff (Harvard Medical School)
Richard Wood (Tufts University)
Robert Schoen (University of Pittsburgh)
Rashmi Sinha (NCI, DCEG)
Meredith Yeager (CGF, NCI)

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