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BMI and the risk of renal cell carcinoma : a case control study

Principal Investigator
Name
Benjamin Chung
Degrees
M.D, M.S.
Institution
Stanford University
Position Title
Associate Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-896
Initial CDAS Request Approval
Jan 18, 2022
Title
BMI and the risk of renal cell carcinoma : a case control study
Summary
Renal cell carcinoma (RCC), or kidney cancer, creates a significant impact not only in the United States, but worldwide and the incidence rate is continuing to rise. The understanding of etiologic factors causing RCC is poorly understood and incomplete, leading to lack of ability from a preventative standpoint, especially in light of both an aging population and an increasing number of younger patients diagnosed with RCC. In light of our frustratingly incomplete knowledge, our aim is to shed additional light on the risk of elevated BMI which has been implicated in the pathogenesis of RCC. As the PLCO dataset has granular information about BMI and specific BMI trends in individual patients, we plan to further explore these correlations, which to our knowledge, have not been reported on previously in the PLCO dataset. The renal dataset appears to be the dataset most relevant to this research study.

In addition, ten evidence-based cancer prevention recommendations including BMI were proposed by the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) in 2018 focused on modifiable risk factors that impact the risk of cancers. To the best of our knowledge, little is known about the role of adherence to WCRF/AICR recommendations on the risk of developing renal cancer in the US adult population. Therefore, we aimed to examine the association between full adherence to the 2018 WCRF/AICR recommendations and the independent impact of BMI on the adherence score and the risk of developing renal cancer in the PLCO cohort.
Aims

1. Assemble a prospective cohort using all participants in the PLCO trial.
2. Assess the risk of RCC with BMI and specific BMI trends, and control for confounders, such as tobacco exposure, medications, and hypertension.
3. Assess the effect of adherence to the 2018 WCRF/AICR recommendations on the risk of developing renal cancer.
4. Assess the impact of BMI as an independent component of a composite score on the risk of developing renal cancer.

Collaborators

Simon Sorensen, Stanford University
Marvin Langston, PhD, Stanford University
Shufeng Li, Stanford University

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