Evaluating key determinants for the risk of second primary lung cancer among bladder cancer survivors using population-based screening trial data from the PLCO
Principal Investigator
Name
Summer Han
Degrees
Ph.D.
Institution
Stanford University
Position Title
Assistant Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-886
Initial CDAS Request Approval
Jan 5, 2022
Title
Evaluating key determinants for the risk of second primary lung cancer among bladder cancer survivors using population-based screening trial data from the PLCO
Summary
Bladder cancer is the second most common genitourinary malignancy. With a rapidly growing number of bladder cancer survivors, the development of subsequent malignancies is a significant concern. Recent studies show that lung cancer (LC) is the most frequent subsequent cancer (i.e., second primary lung cancer [SPLC]) among bladder cancer survivors. While these survivors have high risk of SPLC and mortality, little is known about risk factors for SPLC. Moreover, no specific guidelines exist for cancer survivors who may benefit from tailored risk-based screening strategies that account for personalized treatment and exposure history. Therefore, we aim to identify risk factors, including cancer-specific treatment history, primary tumor characteristics, and lifestyle and behavioral factors, for SPLC and to develop risk prediction models for SPLC among survivors from bladder cancer survivors, to inform efficient risk-stratified survivorship strategies.
Aims
Our specific aims are to identify key determinants for SPLC risk and to build a model for predicting individual SPLC risk for bladder cancer survivors using population-based screening trial data from the PLCO with extended follow-up information via linkage to cancer registry data through 2017.
Collaborators
Summer Han, Eunji Choi, Justin Lee