Evaluating key determinants for the risk of second primary lung cancer among bladder cancer survivors using population-based screening trial data from the PLCO

Principal Investigator

Name
Summer Han

Degrees
Ph.D.

Institution
Stanford University

Position Title
Assistant Professor

Email
summer.han@stanford.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-886

Initial CDAS Request Approval
Jan 5, 2022

Title
Evaluating key determinants for the risk of second primary lung cancer among bladder cancer survivors using population-based screening trial data from the PLCO

Summary
Bladder cancer is the second most common genitourinary malignancy. With a rapidly growing number of bladder cancer survivors, the development of subsequent malignancies is a significant concern. Recent studies show that lung cancer (LC) is the most frequent subsequent cancer (i.e., second primary lung cancer [SPLC]) among bladder cancer survivors. While these survivors have high risk of SPLC and mortality, little is known about risk factors for SPLC. Moreover, no specific guidelines exist for cancer survivors who may benefit from tailored risk-based screening strategies that account for personalized treatment and exposure history. Therefore, we aim to identify risk factors, including cancer-specific treatment history, primary tumor characteristics, and lifestyle and behavioral factors, for SPLC and to develop risk prediction models for SPLC among survivors from bladder cancer survivors, to inform efficient risk-stratified survivorship strategies.

Aims

Our specific aims are to identify key determinants for SPLC risk and to build a model for predicting individual SPLC risk for bladder cancer survivors using population-based screening trial data from the PLCO with extended follow-up information via linkage to cancer registry data through 2017.

Collaborators

Summer Han, Eunji Choi, Justin Lee