Lung Cancer Risk in Cardiovascular Disease and Related Risk Factors
Principal Investigator
Name
Yancen Pan
Institution
University of California, Los Angeles
Position Title
Ph.D. student
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-835
Initial CDAS Request Approval
Sep 24, 2021
Title
Lung Cancer Risk in Cardiovascular Disease and Related Risk Factors
Summary
Lung cancer and cardiovascular disease (CVD) are chronic diseases with high prevalence and incidence. It is wildly accepted that lung cancer and cardiovascular disease (CVD) have common risk factors, such as smoking. However, the lung cancer risk among CVD patients or those experiencing related CVD risk factors, independent with the common risk factors, are unknown.
For the common biological pathway and mechanism, such as inflammation, we hypothesized that lung cancer risk in those who had CVD (stroke and heart attack) or relevant risk (high cholesterol, diabetes and hypertension) were higher than healthy population. And we will test the hypothesis by cohort study design (with Risk Ratio and 95% Confidence Interval).
Meanwhile, for another causal pathway, CVD risk in lung cancer patients is worthwhile to research in our project, in order to better advice the screening guide for current patients
Because PLCO study had a large incident cases of lung cancer, this great dataset will increase power for our project, especially when the mortality of CVD and lung cancer is high (about 20% 5-year survival rate for both diseases).
For the common biological pathway and mechanism, such as inflammation, we hypothesized that lung cancer risk in those who had CVD (stroke and heart attack) or relevant risk (high cholesterol, diabetes and hypertension) were higher than healthy population. And we will test the hypothesis by cohort study design (with Risk Ratio and 95% Confidence Interval).
Meanwhile, for another causal pathway, CVD risk in lung cancer patients is worthwhile to research in our project, in order to better advice the screening guide for current patients
Because PLCO study had a large incident cases of lung cancer, this great dataset will increase power for our project, especially when the mortality of CVD and lung cancer is high (about 20% 5-year survival rate for both diseases).
Aims
1. Figure out lung cancer risk in those who had cardiovascular disease or related risk factors.
2. Figure out the risk of cardiovascular disease or related risk factors in lung cancer patients.
3. Provide reasonable recommendation for lung cancer and cardiovascular disease patients.
Collaborators
Zuo-Feng Zhang, MD, PhD, Distinguished Professor of Epidemiology, Associate Dean for Research, Fielding School of Public Health, University of California, Los Angeles