Evaluating key determinants for the risk of second primary lung cancer among breast and colorectal cancer survivors using population-based screening trial data from the PLCO
Principal Investigator
Name
Summer Han
Degrees
Ph.D.
Institution
Stanford University
Position Title
Assistant Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-683
Initial CDAS Request Approval
Oct 27, 2020
Title
Evaluating key determinants for the risk of second primary lung cancer among breast and colorectal cancer survivors using population-based screening trial data from the PLCO
Summary
Cancer survivors are rapidly increasing in number, with one third (5.4 million) of all cancer survivors are from breast (BC) and colorectal cancer (CRC). Major concerns for cancer survivors include the high risk of developing subsequent malignancies due to genetic susceptibility of hosts, potential harms from treatment (such as radiation) or other distinct exposures. Recent studies show that lung cancer (LC) is one of the most frequent subsequent cancers (i.e. second primary lung cancer (SPLC)) among BC and CRC survivors. While these survivors have high risk of SPLC and mortality, little is known about risk factors for SPLC. Moreover, no specific guidelines exist for cancer survivors who may benefit from tailored risk-based screening strategies that account for personalized treatment and exposure history. Therefore, we aim to identify risk factors, including cancer-specific treatment history, hormone receptor status, primary tumor characteristics, and lifestyle and behavioral factors, for SPLC and to develop risk prediction models for SPLC among survivors from BC and CRC respectively, to inform efficient risk-stratified survivorship strategies.
Aims
Our specific aims are to identify key determinants for SPLC risk and to build a model for predicting individual SPLC risk for BC and CRC survivors using population-based screening trial data from the PLCO with extended follow-up information via linkage to cancer registry data through 2017.
Collaborators
Summer Han (Stanford University),
Eunji Choi (Stanford University),
Victoria Ding (Stanford University),
Sophia Luo (Stanford University),
Justin Lee (Stanford University)
Related Publications
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Development and Validation of a Risk Prediction Model for Second Primary Lung Cancer.
Choi E, Sanyal N, Ding VY, Gardner RM, Aredo JV, Lee J, Wu JT, Hickey TP, Barrett B, Riley TL, Wilkens LR, Leung AN, Le Marchand L, Tammemägi MC, Hung RJ, Amos CI, Freedman ND, Cheng I, Wakelee HA, Han SS
J Natl Cancer Inst. 2021 Jul 13 PUBMED -
Tobacco Smoking and Risk of Second Primary Lung Cancer.
Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP, Riley TL, Huang WY, Kurian AW, Leung AN, Wilkens LR, Robbins HA, Riboli E, Kaaks R, Tjønneland A, Vermeulen RCH, Panico S, Le Marchand L, Amos CI, Hung RJ, ...show more Freedman ND, Johansson M, Cheng I, Wakelee HA, Han SS
J Thorac Oncol. 2021 Mar 12 PUBMED