Consumption of sugar, sugar-sweetened beverages and liver cancer
To date, few studies have examined the association between liver cancer and consumption of sugar or SSB. In 2000, a small Greek case-control study reported no overall association with sugar consumption, but did not examine SSB. In 2012, an NIH-AARP cohort study of 24 cancers reported no associations with liver cancer and total sugar, added sugar, total fructose or sucrose, but the analysis was limited to examining 222 cases among men and 66 cases among women. In contrast, a 2013 study in the EPIC cohort reported a significant association between total sugar consumption and liver cancer (HR=1.43, 95%CI=1.17-1.74). Given the inconsistency of the results, further examination of the sugar-liver cancer association, and in particular, the SSB-liver cancer association, is clearly warranted.
To examine the association of liver cancer with:
1) Consumption of sugar-sweetened beverages (regular soda, diet soda, juices);
2) Sugar (sugar, artificial sweeteners) added to coffee and tea.
Gieira Jones, DCEG-NCI
Barry Graubard, DCEG-NCI
Jessica Petrick, Boston University
Xuehong Zhang, Harvard University
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Sweetened beverage consumption and risk of liver cancer by diabetes status: A pooled analysis.
Jones GS, Graubard BI, Ramirez Y, Liao LM, Huang WY, Alvarez CS, Yang W, Zhang X, Petrick JL, McGlynn KA
Cancer Epidemiol. 2022 Jun 18; Volume 79: Pages 102201 PUBMED