Estimate heritability of survival for selected diseases
Principal Investigator
Name
Jianxin Shi
Degrees
PhD
Institution
National Cancer Institute
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-661
Initial CDAS Request Approval
Aug 20, 2020
Title
Estimate heritability of survival for selected diseases
Summary
While genome-wide association studies (GWAS) have identified many loci for disease risk, GWAS for survival have not been productive. This raises a question whether there is strong genetic component for survival traits for complex diseases, including cancers. This question can be answered by estimating the heritability of survival traits. We have recently developed two complimentary statistical methods for estimating the heritability of survival traits, one based linear mixed model and the other based on cox's model and we have used extensive simulations to verify that our approach can unbiasly estimAte heritability of survival.
We plan to perform survival heritability analysis for a few diseases with more than 4000 cases in the PLCO GWAS, including prostate cancer, breast cancer, lung cancer, colorectal cancer and a few other complex diseases, e.g. cardiovascular diseases.
We plan to perform survival heritability analysis for a few diseases with more than 4000 cases in the PLCO GWAS, including prostate cancer, breast cancer, lung cancer, colorectal cancer and a few other complex diseases, e.g. cardiovascular diseases.
Aims
This project aims to estimate the heritability of survival for selected diseases with more than 4000 patients in PLCO GWAS.
Collaborators
Dr. Sung Duk Kim, DCEG, NCI
Dr. Wenyi Huang, DCEG, NCI
Dr. Mitchell Machiela, DCEG, NCI