Risk Factors for Lung Cancer in Never Smokers: Insight from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Dataset
Principal Investigator
Name
Farouk Dako
Degrees
MD., MPH
Institution
University of Pennsylvania
Position Title
Assistant Professor
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-660
Initial CDAS Request Approval
Aug 18, 2020
Title
Risk Factors for Lung Cancer in Never Smokers: Insight from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Dataset
Summary
Lung cancer continues to be the leading cause of cancer death in the world. It has a well-established strong causal association with smoking as 80- 90% of lung cancers occur in smokers. Research into risk factors for lung cancer not due to smoking and other inhaled toxins has yielded conflicting and inconclusive results. A significant barrier to addressing this issue is the paucity of large population level data sets on lung cancer in never smokers which are needed to eliminate the effects of smoking as a confounding variable and an effect modifier. Our project aims to utilize PLCO, an extensive prospectively collected data set, to further assess variables that represent known and potential risk factors for lung cancer in never smokers .
Aims
Identify associations with lung cancer in never smokers incidence based on data from the administered questionnaires. Responses would be grouped into
-Demographics
-Lifestyle and Anthropometry
-Medical History
-Medication Use data
Perform multivariate analysis to identify potential risk factors for lung cancer in never smokers
Collaborators
None