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Comparative Effectiveness of Different Lung Cancer Treatments

Principal Investigator

Name
Chi-Fu Yang

Degrees
M.D.

Institution
Stanford

Position Title
Fellow

Email
cjyang@post.harvard.edu

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-675

Initial CDAS Request Approval
Jun 9, 2020

Title
Comparative Effectiveness of Different Lung Cancer Treatments

Summary
Currently, numerous national retrospective studies of clinical and administrative databases have evaluated the effectiveness of different treatments for stage I-IV lung cancer. However, those databases are often missing important information, such as data on COPD or smoking history. The objective of this research project is to evaluate the effectiveness of different treatments for stage I-IV lung cancer using the NLST, which contains important variables such as COPD or smoking history.

Aims

Aim #1: To compare the outcomes associated with different surgical and non-operative treatments for stage I-IV lung cancer

Aim #2: To evaluate the impact of delays to care on short-term and long-term outcomes on patients with stage I-IV lung cancer.

Aim #3: To evaluate the outcomes associated with delayed treatment vs timely treatment and evaluate optimal time intervals for treatment for stage I-IV lung cancer.

Aim #4: To identify patterns and trends in lung cancer care and outcomes that are related to socioeconomic and racial disparities.

Aim #5: To evaluate how various patient demographic, clinical, and pathologic factors could be associated with or impact short-term and long-term outcomes for patients with stage I-IV lung cancer.

Aim #6: To develop risk prediction models that address Aims #1-#6

Collaborators

Nicholas Mayne, Duke
Vignesh Raman, Duke
John Deng, UCLA
Yoyo Wang, Michigan
Alexandra Potter, UC Berkeley
Alice Darling, Duke
Holly Elser, Stanford
Douglas Liou, Stanford
Belle Lin, University of Arizona

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