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Principal Investigator
Name
Erikka Loftfield
Degrees
Ph.D., M.P.H.
Institution
National Cancer Institute
Position Title
Research Fellow
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2020-9001
Initial CDAS Request Approval
Mar 18, 2020
Title
EEMS Methods Study Work
Summary
This EEMS study will contain all of the methods work done for PLCO EEMS under one umbrella. Each methods project will be entered in as its own addendum for tracking purposes.
Aims

1. To facilitate methods studies in the PLCO EEMS project.

Collaborators

Erikka Loftfeld (NIH/DCEG)

Approved Addenda This project has one or more approved addenda.
  • Characterizing variability of F2-isoprostane measurements in plasma: a pilot study
  • QC Samples for a pilot study to compare two assay platforms for measuring prolactin
  • Cigarette Smoking, oral microbiome and lung cancer
  • To conduct a RNA extraction pilot from PLCO frozen whole blood samples.
  • Understanding the I179T Amino Acid Change in Prostate Specific Antigen
  • A Pilot Study of a Vitamin D Binding Protein Assay
  • PLCO Mosaicism Sorting Pilot
  • Blood-Based (BB) Risk Prediction Model for Lung Cancer
  • Measure Concentration of PSA in samples
  • Expand on our ability to sort preserved whole blood samples into cellular lineages, extract DNA, and run SNP microarrays
  • To develop/validate extraction protocols and systems for PLCO samples
  • Freeze / Thaw Experiments
  • High Throughput Extraction for GSA
  • PLCO DNA extraction pilot
  • Pilot study of trace and ultra-trace elements measures in frozen RBCs
  • Proof of Concept Study - Maxpar Direct Immune Profiling Assay
  • The Effect of Preanalytical Conditions on Blood Biomarkers
  • Prospective study of DNA repair functional assays and risk of lung cancer: A preliminary pilot study with samples of healthy subjects cryopreserved using the PLCO Trial T3 protocol
  • EDTA plasma for metabolomics QC work