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Principal Investigator
Name
Vincent Cryns
Degrees
M.D.
Institution
University of Wisconsin Madison
Position Title
Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-579
Initial CDAS Request Approval
Feb 7, 2020
Title
Evaluation of dietary methionine intake and breast cancer incidence
Summary
Breast cancer is the most commonly diagnosed cancer in women regardless of race and ethnicity and is one of the leading causes of cancer death in women in the United States. Recent work into the epigenome has found epigenetic dysfunction to be a commonly occurring event in many cancer types and pre-cancerous lesions, including breast cancer. Large-scale alterations in both DNA and chromatin methylation have been implicated in the development of cancer and the exposure of certain DNA segments not normally expressed in terminally differentiated cell types. Altered histone methylation has also been implicated in the epithelial-to-mesenchymal transition and acquisition of a stem-like state, suggesting epigenetic dysfunction may also contribute to cancer invasiveness and chemotherapy resistance. S-adenosylmethionine (SAM) is the universal methyl donor for nucleotide and chromatin methylation and is synthesized from the essential amino acid methionine. SAM availability has been shown to fluctuate in response to dietary methionine intake, suggesting dietary methionine content plays a role in methyl group availability and may influence epigenetic dysfunction seen in breast cancer. Dietary methionine restriction is also currently being evaluated as a therapeutic strategy to target tumor cells and regress existing tumor growth as well as sensitize tumor cells to existing chemotherapies. Thus we hypothesize dietary methionine intake may influence breast cancer incidence within the PLCO dataset population.
Aims

To evaluate the association between dietary methionine intake and the incidence of breast cancer in woman

Collaborators

Joni Sedillo, University of Wisconsin Madison
Christopher Bradfield, PhD, University of Wisconsin Madison