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Analyses using GWAS data from PLCO to evaluate genetic impact on colorectal screening and outcomes

Principal Investigator
Name
Wen-Yi Huang
Degrees
Ph.D., M.S.P.H.
Institution
National Cancer Institute
Position Title
Epidemiologist
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-560
Initial CDAS Request Approval
Dec 11, 2019
Title
Analyses using GWAS data from PLCO to evaluate genetic impact on colorectal screening and outcomes
Summary
In collaboration with the GECCO consortium, we request GWAS and covariates data from PLCO participants to evaluate the impact of genetic risk stratification using polygenic risk scores (PRS) on colorectal screening decisions and outcomes. Some specific aims are as follows.
Aims

Aim 1: Generate PRS using data from GECCO

Aim 2: PRS and risk of adenoma and advanced adenoma

Aim 3: PRS and surveillance decisions

Aim 4: PRS and risk of recurrent adenoma

Aim 5: Explore risk factor profiles of subjects in the extremes of the PRS

Collaborators

Neal Freedman
Sonja Berndt
Erikka Loftfield
Hormuzd Katki
Rebecca Landy
Ulrike Peters
Robert E Schoen
Li Hsu

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