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Blood metabolomics, smoking and lung cancer risk

Principal Investigator

Name
Wei Jie Seow

Degrees
Sc.D.

Institution
National University of Singapore

Position Title
Assistant Professor

Email
ephswj@nus.edu.sg

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-558

Initial CDAS Request Approval
Dec 16, 2019

Title
Blood metabolomics, smoking and lung cancer risk

Summary
Lung cancer is the leading cause of cancer mortality that accounted for 1.6 million deaths worldwide. Metabolomics is the rapid, high-throughput detection and quantification of small-molecules such as metabolite intermediates, food components and hormones found in an organism. The relationships of these metabolites with lung cancer risk are still largely unknown. Therefore, we propose to identify the associations between metabolite levels and lung cancer risk in the PLCO that measured pre-diagnostic blood metabolite levels. We also propose to assess the association between smoking and blood metabolites.

Aims

Aim 1: To examine the association between pre-diagnostic blood metabolite levels and lung cancer risk in the PLCO.
Aim 2: To identify metabolites that are associated with smoking.

Collaborators

Dr. Steve Moore, Dr. Nathan Appel

Related Publications