Serum Testosterone and Subsequent Risk of Urologic and Non-Urologic Cancer
Principal Investigator
Name
Joshua Halpern
Degrees
MD, MS
Institution
Northwestern University Feinberg School of Medicine
Position Title
Assistant Professor of Urology
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-528
Initial CDAS Request Approval
Sep 26, 2019
Title
Serum Testosterone and Subsequent Risk of Urologic and Non-Urologic Cancer
Summary
While the relation between testosterone and prostate cancer has been well-delineated, the effects of testosterone on other cancer is unclear. Small cohort studies have demonstrated potential pathophysiologic mechanisms through which testosterone may impact the incidence and severity of disease in lung cancer, colon cancer, and esophageal cancer. However, there are very few studies examining the association between testosterone and subsequent cancer risk in the general population. The aim of this project is to determine the association between serum testosterone and subsequent risk of cancer among men.
Aims
- To determine the association between baseline serum testosterone and subsequent risk of lung, colon, and other non-urologic cancers among men
- To determine the association between baseline serum testosterone and subsequent risk of kidney and bladder
- To determine the association between baseline and cancer grade / stage at presentation in the above cancers
Collaborators
Edward M. Schaeffer
Mary Kate Keeter