Skip to Main Content

An official website of the United States government

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Genome-wide association study (GWAS) for second primary lung cancer (SPLC) in PLCO

Principal Investigator
Name
Summer Han
Degrees
Ph.D
Institution
Stanford University
Position Title
Assistant Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-511
Initial CDAS Request Approval
Aug 23, 2019
Title
Genome-wide association study (GWAS) for second primary lung cancer (SPLC) in PLCO
Summary
We aim to identify genetic risk factors associated second primary lung cancer (SPLC) among lung cancer patients. We will use outcome variable defined as: SPLC status (0: censored, 1: SPLC, 2: death from LC or other causes) and associated event time (e.g. diagnosis date, death date, etc.). We plan to use GWAS data (including genotyped data and imputed SNP data) for PLCO. We will run competing risk regression models (Fine and Gray regression and Cause-specific Cox hazards model) for each SNP adjusting for a set of covariates. The covariate list(s) will be provided. We plan to conduct two-stage analysis, where Stage 1 is focusing only on analyzing ~120 SNPs of interest (selected from the literature, list to be provided) and Stage 2 will be analyzeingthe entire GWAS data (genotyped and imputed).
Aims

To identify genetic variants associated with SPLC risk

Collaborators

NA