Genome-wide association study (GWAS) for second primary lung cancer (SPLC) in PLCO

Principal Investigator

Name
Summer Han

Degrees
Ph.D

Institution
Stanford University

Position Title
Assistant Professor

Email
summer.han@stanford.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-511

Initial CDAS Request Approval
Aug 23, 2019

Title
Genome-wide association study (GWAS) for second primary lung cancer (SPLC) in PLCO

Summary
We aim to identify genetic risk factors associated second primary lung cancer (SPLC) among lung cancer patients. We will use outcome variable defined as: SPLC status (0: censored, 1: SPLC, 2: death from LC or other causes) and associated event time (e.g. diagnosis date, death date, etc.). We plan to use GWAS data (including genotyped data and imputed SNP data) for PLCO. We will run competing risk regression models (Fine and Gray regression and Cause-specific Cox hazards model) for each SNP adjusting for a set of covariates. The covariate list(s) will be provided. We plan to conduct two-stage analysis, where Stage 1 is focusing only on analyzing ~120 SNPs of interest (selected from the literature, list to be provided) and Stage 2 will be analyzeingthe entire GWAS data (genotyped and imputed).

Aims

To identify genetic variants associated with SPLC risk

Collaborators