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Body-mass index and mortality among US Latinos

Principal Investigator
Name
Amy Berrington de González
Degrees
D.Phil.
Institution
National Cancer Institute
Position Title
Branch Chief and Senior Investigator
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-450
Initial CDAS Request Approval
Jan 28, 2019
Title
Body-mass index and mortality among US Latinos
Summary
A high body-mass index (BMI) is associated with increased mortality among white individuals, but the relationship between BMI and mortality among US Latinos has been rarely studied and results are often difficult to interpret due to methodological issues. Therefore, the aim of this project is to explore the association between BMI and all-cause mortality and mortality from broad category of diseases including cardiovascular disease, cancer, endocrine disease, respiratory disease and digestive disease among US Latino population. To do so, we propose to conduct survival analyses using the PLCO dataset to estimate hazard ratios for an association between BMI and mortality, adjusting for potential confounding factors, such as demographics, general health, smoking, alcohol consumption and physical activities.
Aims

1. To examine the association between BMI and all-cause mortality among US Latino population
2. To examine the association between BMI and mortality from broad disease categories, such as cardiovascular disease, cancer, respiratory disease, endocrine, and digestive disease.

Collaborators

Neal Freedman, National Cancer Institute
Cari Meinhold Kitahara, National Cancer Institute
Meredith Shiels, National Cancer Institute

Related Publications
  • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.
    Global BMI Mortality Collaboration , Di Angelantonio E , Bhupathiraju ShN , Wormser D , Gao P , Kaptoge S , Berrington de Gonzalez A , Cairns BJ , Huxley R , Jackson ChL , Joshy G , Lewington S , Manson JE , Murphy N , Patel AV , Samet JM , Woodward M , Zheng W , Zhou M , Bansal N , ...show more Barricarte A , Carter B , Cerhan JR , Smith GD , Fang X , Franco OH , Green J , Halsey J , Hildebrand JS , Jung KJ , Korda RJ , McLerran DF , Moore SC , O'Keeffe LM , Paige E , Ramond A , Reeves GK , Rolland B , Sacerdote C , Sattar N , Sofianopoulou E , Stevens J , Thun M , Ueshima H , Yang L , Yun YD , Willeit P , Banks E , Beral V , Chen Zh , Gapstur SM , Gunter MJ , Hartge P , Jee SH , Lam TH , Peto R , Potter JD , Willett WC , Thompson SG , Danesh J , Hu FB
    Lancet. 2016 Aug 20; Volume 388 (Issue 10046): Pages 776-86 PUBMED