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Diet, Metabolic Biomarkers and Lung Cancer Risk

Principal Investigator
Name
Martin Carl Tammemagi
Degrees
D.V.M, M.Sc., Ph.D.
Institution
Brock University
Position Title
Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-418
Initial CDAS Request Approval
Nov 19, 2018
Title
Diet, Metabolic Biomarkers and Lung Cancer Risk
Summary
Previously, we carried out the study Insulin Resistance and Lung Cancer Risk (Project ID 2012-0001). The study was a nested case controlled study in which we found in ever-smokers, that higher pre-diagnosis C-peptide and highly sensitive C-reactive protein (hsCRP) were associated with higher lung cancer risk, and leptin and BMI were inversely associated with lung cancer. A manuscript describing these finding has been prepared and will be submitted shortly. We wish to extend our study by investigating the role that dietary factors may play in relationship to the metabolic biomarkers under study and to lung cancer.
For analysis, we will merge on an individual level PLCO dietary data from the two nutritional surveys with our original nested case-control data, which now is complete with biomarker data.
Aims

We plan to carry out random forest analysis to find which dietary factors or patterns of factors are associate with lung cancer risk.
Using conditional univariable and multivariable logistic regress, we will then attempt to determine whether the nutritional effects are mediated through the biomarkers under study (C-peptide, hsCRP, and leptin).
We will additionally evaluate whether observed associations are modified (effect modification) by smoking exposure, sex, and histological lung cancer type.

Collaborators

Pamela J. Goodwin (Samuel Lunenfeld Research Institute at Mount Sinai Hospital, University of Toronto)
Frances A. Shepherd (Princess Margaret Hospital, University Health Network, University of Toronto)
Geoffrey Liu (Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto)
Ming-Sound Tsao (Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto)
Natasha B. Leighl (Princess Margaret Hospital, University Health Network, University of Toronto)
Vuk Stambolic (Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto)
Crystal Chen (Brock University)