Physical activity, PSA levels, and screen-detected prostate cancers.
Principal Investigator
Name
Yelena Tarasenko
Degrees
DrPH, CPH, MPH
Institution
Georgia Southern University
Position Title
Associate Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-415
Initial CDAS Request Approval
Oct 23, 2018
Title
Physical activity, PSA levels, and screen-detected prostate cancers.
Summary
There is considerable evidence that physical activity can reduce the risk of colorectal, breast, and endometrial cancer. However, the evidence for a relationship between prostate cancer and physical activity is more limited and mixed. In addition, one study has suggested an inverse association with more aggressive, high-grade tumors but not lower grade tumors. Tangentially, results from the National Health and Nutrition Examination Survey have shown that increased physical activity levels are associated with lower PSA levels. The lower PSA levels could represent biologic evidence of a mechanism which reduces risk or, alternatively, an artifactual reduction due to decreased detection of prostate cancer tumors from PSA testing. Because prostate cancer is the leading cause of cancer and second leading cause of cancer death among men, even small reductions in risk can affect a large number of men. We are proposing to further examine the prospective relationship between physical activity, PSA levels, and risk of prostate cancer incidence using men in the PLCO who completed the Supplemental Questionnaire (SQX).
Aims
The aim of our study are as follows:
1. To assess the association between physical activity and prostate cancer incidence and mortality in a prospectively followed population;
(1a) to examine if potential associations differ by tumor grade.
2. To assess the association between physical activity level and PSA levels and potential impact on rates and tumor characteristics.
Collaborators
Eric A. Miller, PhD (Division of Cancer Prevention, NCI)
Daniel F. Linder, PhD (Medical College of Georgia, Augusta University)