Levels of Trimethylamine Metabolites and Their Associations with Dietary Intakes and Cardiometabolic Biomarkers: the TMAO Pooling Project
Principal Investigator
Name
Danxia Yu
Degrees
Ph.D.
Institution
Vanderbilt University Medical Center
Position Title
Assistant Professor
Email
danxia.yu@vanderbilt.edu
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-414
Initial CDAS Request Approval
Nov 2, 2018
Title
Levels of Trimethylamine Metabolites and Their Associations with Dietary Intakes and Cardiometabolic Biomarkers: the TMAO Pooling Project
Summary
There is a growing appreciation that diet-gut microbiota interactions play an important role in human cardiovascular health. Recent studies have discovered a diet-derived, gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which may promote the development of cardiovascular disease (CVD). So far, only a few small studies among general populations have investigated this novel TMAO-CVD pathway. Limited evidence suggests that TMAO production and metabolism is influenced by both dietary and non-dietary factors and that the diet-TMAO association may vary across populations due to significant variations in TMAO food sources (e.g., meat vs. fish vs. plant foods). Large-scale, collaborative epidemiologic studies that include ethnically and regionally diverse populations and incorporate comprehensive data on diet, TMAO metabolites, and CVD biomarkers will provide critical insights into this meta-organismal pathway and may pave the way for developing new strategies for CVD prevention and treatment based on diet-gut microbiota interactions. We propose to conduct a consortium-based, secondary data analysis, the TMAO Pooling Project, based on the Consortium of Metabolomics Studies (COMETS).
Aims
• To examine levels of TMAO metabolites across populations and their associations with age, sex, race/ethnicity, obesity, lifestyle factors (e.g., smoking), and metabolic diseases (e.g., diabetes, hypertension, and dyslipidemia).
• To evaluate associations of TMAO metabolites with dietary intakes, including red meat, poultry, eggs, dairy, fish, shellfish, legumes, nuts, vegetables, fruits, macronutrients, and fiber.
• To evaluate associations of TMAO metabolites with CVD biomarkers, including blood lipids, glucose, insulin, blood pressure, and inflammatory and renal function markers.
Collaborators
Steven C. Moore, PhD, MPH, National Cancer Institute;
Xiao-Ou Shu, MD, PhD, Vanderbilt University Medical Center;
Hui Cai, MD, PhD, Vanderbilt University Medical Center;
Thomas J. Wang, MD, Vanderbilt University Medical Center;
Loren P. Lipworth, ScD, Vanderbilt University Medical Center;
David M. Herrington, MD, MHS, Wake Forest School of Medicine;
Heather A. Eliassen, ScD, Harvard T.H. Chan School of Public Health;
Katie A. Meyer, ScD, University of North Carolina;
Nicholette D. Allred, PhD, Wake Forest School of Medicine;
Marinella Temprosa, PhD, George Washington University;
Demetrius Albanes, MD, National Cancer Institute;
Cristina Menni, PhD, King's College London;
Ioanna Tzoulaki, PhD, Imperial College London;
Gard Frodahl Tveitevåg Svingen, MD, PhD, Haukeland University Hospital;
Huilian Zhu, MD, PhD, Sun Yat-sen University;
Sei Harada, MD, PhD, Keio University;