Validation of Liverpool Lung Project (LLP) Model Version 3

Principal Investigator

Name
Hilary Robbins

Degrees
PhD MHS MSPH

Institution
Queen Mary University of London

Position Title
Visiting researcher

Email
hrobbins827@gmail.com

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-380

Initial CDAS Request Approval
Jul 5, 2018

Title
Validation of Liverpool Lung Project (LLP) Model Version 3

Summary
We are developing an updated version of the Liverpool Lung Project (LLP) risk prediction model for incident lung cancer (LLPv3). We plan to use PLCO data to validate our model and examine possible risk thresholds for selecting ever-smokers into lung screening.

Aims

1) Externally validate the LLPv3 model by calculating measures of calibration (ratio of expected to observed lung cancer cases) and discrimination (area under the ROC curve statistic [AUC]).
3) Examine potential risk thresholds for selecting ever-smokers into lung screening by calculating the proportion of ever-smokers selected, sensitivity, and specificity of different risk thresholds.

Collaborators

Stephen Duffy, Queen Mary University of London
John Field, University of Liverpool