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Validation of Liverpool Lung Project (LLP) Model Version 3

Principal Investigator
Name
Hilary Robbins
Degrees
PhD MHS MSPH
Institution
Queen Mary University of London
Position Title
Visiting researcher
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-380
Initial CDAS Request Approval
Jul 5, 2018
Title
Validation of Liverpool Lung Project (LLP) Model Version 3
Summary
We are developing an updated version of the Liverpool Lung Project (LLP) risk prediction model for incident lung cancer (LLPv3). We plan to use PLCO data to validate our model and examine possible risk thresholds for selecting ever-smokers into lung screening.
Aims

1) Externally validate the LLPv3 model by calculating measures of calibration (ratio of expected to observed lung cancer cases) and discrimination (area under the ROC curve statistic [AUC]).
3) Examine potential risk thresholds for selecting ever-smokers into lung screening by calculating the proportion of ever-smokers selected, sensitivity, and specificity of different risk thresholds.

Collaborators

Stephen Duffy, Queen Mary University of London
John Field, University of Liverpool