Use of GWAS data to address the association between Human Leukocyte Antigen (HLA) and cancer
1) Which cancers have/do not have genetic associations within the MHC region
2) Do cancers associated with EBV infection have stronger evidence for genetic associations within the HLA Class I region, other infection-associated cancers and hematopoetic cancers have stronger evidence for associations within the HLA Class II regions, and other solid tumors with no know infectious cause either have no evidence of associations in the MHC region or have stronger evidence for associations within the non-HLA Class I/II regions of the MHC.
Ruth Pfeiffer, NCI/DCEG
Andriy Derkach, NCI/DCEG
Kelly Yu, NCI/DCEG
Zhiwei Liu, NCI/DCEG
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Association Between Human Leukocyte Antigen Class I and II Diversity and Non-virus-associated Solid Tumors.
Liu Z, Hildesheim A
Front Genet. 2021; Volume 12: Pages 675860 PUBMED -
Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer.
Liu Z, Derkach A, Yu KJ, Yeager M, Chang YS, Chen CJ, Gyllensten U, Lan Q, Lee MH, McKay JD, Rothman N, Yang HI, Hildesheim A, Pfeiffer RM
Cancer Res. 2021 Feb 15; Volume 81 (Issue 4): Pages 1148-1152 PUBMED