A genome-wide association study of lifecourse weight change
Principal Investigator
Name
Sonja Berndt
Degrees
Pharm.D., Ph.D.
Institution
National Cancer Institute
Position Title
Senior Investigator
Email
berndts@mail.nih.gov
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-325
Initial CDAS Request Approval
Nov 27, 2017
Title
A genome-wide association study of lifecourse weight change
Summary
In the United States, approximately 69% of those age ≥20 years are overweight [body mass index (BMI ≥ 25.0) while 36% are obese (BMI ≥30.0). Overweight and obesity increases risk of diabetes, coronary artery disease, stroke, and several cancers as well as psychosocial and economic difficulties. Genetic variants have been recognized as an important factor in weight status (healthy, overweight, obese). Genome-wide association studies have been successful in identifying common loci associated with weight (e.g., BMI and weight circumference), however, these studies have been restricted to evaluating weight status cross-sectionally. To date, studies assessing the relationship between obesity related genes and longitudinal weight change have been unsuccessful. To our knowledge, there are no genome-wide association studies that examined weight change phenotypes longitudinally. Improved understanding of the genetic basis underlying weight change would provide insights into mechanisms of obesity and potential predictive markers for treatment. Therefore, the proposed study will utilize whole-genome data in PLCO to identify genetic variants associated with weight change phenotypes throughout adulthood. Patterns of weight change across adulthood will be identified using retrospectively collected weight information and weight information collected at baseline for each participant.
Aims
The purpose of this study is to determine the association of genetic variants with weight change in adults.
Collaborators
Erik A. Willis, PhD, MPH, Cancer Prevention Fellow
Chuck E. Matthews, PhD, Senior Investigator
Tanya Agurs-Collins, PhD, RD, Program Director