Metabolomics Profiles for Colorectal Cancer Risk Prediction within prospective Cohorts in th COMETS Consortium

Principal Investigator

Name
Jennifer Ose

Degrees
PhD, MSc, Dipl. oec. troph.

Institution
Huntsman Cancer Institute, University of Utah

Position Title
Assistant Professor on Research Track

Email
jennie.ose@hci.utah.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-320

Initial CDAS Request Approval
Oct 31, 2017

Title
Metabolomics Profiles for Colorectal Cancer Risk Prediction within prospective Cohorts in th COMETS Consortium

Summary
Our overarching goal is to use the unique resource of the COMETS consortium to discover and validate novel blood-based metabolite biomarkers that predict risk and/or detect recurrence among CRC patients.

Aims

We propose to investigate the association of blood-based metabolomics data from targeted analyses in samples from CRC patients and healthy controls using a discovery set (n=tbd) and a validation set (n=tbd) across multiple studies participating in COMETS.
Aim 1: To identify metabolomic profiles of colorectal cancer risk in prospectively collected blood samples
Secondary Aims: Examine whether the metabolomic profiles of colorectal cancer identified differ by tumor stage, MSI status and other factors of tumor profile, race/ethnicity, family history, or other factors.

Collaborators

Steve Moore, NIH,
Marc Gunter, Imperial College of London, London, GB
Neli Ulrich, Huntsman Cancer Institute, Utah, USA