Expanded Genome-wide Association Study of Lymphoid Malignancies and Related Disorders
Principal Investigator
Name
Sonja Berndt
Degrees
Ph.D.,Pharm.D.
Institution
National Cancer Institute
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-298
Initial CDAS Request Approval
Aug 24, 2017
Title
Expanded Genome-wide Association Study of Lymphoid Malignancies and Related Disorders
Summary
Discovering the genetic basis of lymphoid malignancies (LM) and related disorders is critical for understanding their etiology. With the advent of genome-wide association studies (GWAS) and through the success of pooled analyses of the InterLymph Consortium, tremendous progress has been made in identifying genetic variants associated with risk of specific LM subtypes. To date, our GWAS for non-Hodgkin lymphoma (NHL) has discovered over 35 independent single nucleotide polymorphisms (SNPs) for specific subtypes of NHL, making a substantial contribution to our understanding of genetic susceptibility to this disease. Multiple loci have also been identified for multiple myeloma (MM) and Hodgkin lymphoma (HL) through GWAS conducted within the InterLymph Consortium and other groups. However, these SNPs only explain a fraction of the heritability of common LM subtypes, and little is known regarding the heritability of less common LM subtypes. We are currently expanding our previous GWAS to conduct a larger and more comprehensive GWAS to identify the genetic variants that contribute to the etiology of LM and influence survival. We propose to include all LM cases and controls from PLCO with available genome-wide association data in our LM GWAS. This project will make fundamental and important contributions to our knowledge of the etiology of LM as well as inherited determinants of survival, which may be useful in developing new disease management and treatment strategies in the future.
Aims
1.To conduct a genome-wide association study of LM, to identify new genetic loci for specific LM subtypes and LM overall, and to conduct in depth subtype analyses and comparisons
2.To identify loci associated with survival and other related outcomes
3.To conduct further pathway, gene-gene, gene-environment, and heritability analyses as directed by the NHL/LM GWAS Coordinating Committee or proposed by study investigators
Collaborators
Sonja Berndt (Co-PI; NCI)
Nathaniel Rothman (Co-PI; NCI)
Jonathan Hofmann (Co-PI; NCI)
Bryan Bassig (NCI)
Qing Lan (Co-PI; NCI)