Melanoma GWAS
Principal Investigator
Name
Maria Teresa Landi
Degrees
M.D., Ph.D.
Institution
NIH, NCI
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-268
Initial CDAS Request Approval
Apr 5, 2017
Title
Melanoma GWAS
Summary
We are conducting a melanoma GWAS across multiple centers in subjects of European ancestry. We are respectfully requesting GWAS data from PLCO to be included in the current GWAS to increase the sample size and the probability to identify new genetic loci. Specifically, we would like to receive data from all cutaneous melanoma cases and non-cancer controls of European ancestry genotyped at CGR. We plan to impute the data using the Haplotype Cancer Consortium as a reference.
If the data are available in a large set of individuals, we plan to also conduct a Mendelian randomization study in the future to study the SNPs involved in Vitamin D metabolism in relation to melanoma risk and clinical outcomes
If the data are available in a large set of individuals, we plan to also conduct a Mendelian randomization study in the future to study the SNPs involved in Vitamin D metabolism in relation to melanoma risk and clinical outcomes
Aims
1. To conduct a meta-analysis of GWAS data from cutaneous melanoma cases and non-cancer controls to identify genetic loci for melanoma risk and, possibly, survival
2. To conduct a Mendelian randomization study to explore the effect of Vitamin D in relation to melanoma risk and clinical outcomes, using SNPs in the Vitamin D receptor
Collaborators
Drs. Jianxin Shi, Mitch Machiela, Kevin Brown, Alisa Goldstein, Rose Yang, Lei Song, Belynda Hicks; DCEG/NCI
Drs. Matthew Law and Stuart McGregor, University of Brisbane, Australia
Drs. Mark Iles and Tim Bishop, University of Leeds, UK
Dr. Florence Demenais, INSERM, Paris, France