Genetic ancestry of African Americans who have been already genotyped in PLCO

Principal Investigator

Name
Neal Freedman

Degrees
PhD, MPH

Institution
NCI

Position Title
Senior Investigator

Email
freedmanne@mail.nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-263

Initial CDAS Request Approval
Mar 1, 2017

Title
Genetic ancestry of African Americans who have been already genotyped in PLCO

Summary
We are conducting a study of individuals with varying degrees of African ancestry, including East Africans, West Africans, Africans from the Caribbean, African-Americans, Brazilians, etc. in order to determine the African diaspora across much of the globe. There are a number of PLCO subjects that were genotyped at CGR in various GWAS that were subsequently determined to have significant African ancestry (determined genetically, approximately 500 of them) and therefore excluded from GWAS analyses of Europeans and Asians. We would also like to ask that we are provided birth year for the subjects so we can calibrate likely admixture dates for each subject. This project will ultimately be published and is using thousands of individuals from both publicly-available sources and through collaborations with other academic investigators.

Aims

We would like to determine genetic admixture of African Americans in PLCO using already generated GWAS data.

Collaborators

Meredith Yeager, Cancer Genomics Research Laboratory, NCI: yeagerm@mail.nih.gov