Lifestyle changes after a cancer diagnosis in relation to all-cause and cancer-specific mortality
Principal Investigator
Name
Hannah Brooke
Degrees
M.Phil., Ph.D.
Institution
Karolinska Institutet
Position Title
Post-doctoral fellow
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-245
Initial CDAS Request Approval
Dec 16, 2016
Title
Lifestyle changes after a cancer diagnosis in relation to all-cause and cancer-specific mortality
Summary
Lifestyle factors, such as diet, physical activity, smoking status, alcohol intake, and use of common analgesics, are known to influence the risk of cancer occurrence. However, studies examining lifestyle factors in relation to survival are less common. Most studies that have attempted address these questions have used lifestyle factors measured at one point in time. However, whether change in lifestyle after a cancer diagnosis can influence survival independent of pre-cancer lifestyle has high clinical relevance, but has received little attention to date. As cancer diagnostics and treatments continue to improve, the group of cancer survivors, for whom this is an important question, continues to increase. A better understanding of this topic in necessary to help clinicians offer advice to their patients and to help patients make informed decisions about their lifestyle following a cancer diagnosis. Examining such a research question using observational data can complement results from intervention studies by presenting a real-world perspective.
Aims
To examine whether a change in lifestyle (diet, physical activity, smoking status, alcohol intake, and use of common analgesics) after a cancer diagnosis (all types pooled and stratified by major subtypes) is associated with survival (all-cause and cancer-specific mortality) and risk of a second primary cancer diagnosis.
Collaborators
Prof Maria Feytching (Ph.D.), Karolinska Institutet, Sweden
Dr Magnus Lindskog (M.D., Ph.D.), Uppsala Universitet, Sweden
Ms Hanna Mogensen (M.Sci.), Karolinska Institutet, Sweden
Dr Rickard Ljung (M.D., Ph.D.), Karolinska Institutet, Sweden