A Genome-Wide Scan to Detect Loci Associated with Multiple Primary Cancers
The proposed study will use a case-control design. Cases will be European-ancestry participants with genotype data and at least two pathologically confirmed cancers as defined by the SEER multiple primary rules. Controls will be all European-ancestry participants with genotype data who have never been diagnosed with any cancer, except non-melanoma skin cancer. With approximately 15,345 primary cancer diagnoses within GWAS data in PLCO, and assuming a 5.74% rate of second cancers, we expect around 881 cases of multiple primary cancers for our proposed analysis.
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Specific Aim 1: Evaluate the association between genetic variants and risk of multiple cancers by performing a GWAS in a population-based prospective cohort.
Specific Aim 2: Explore the potential for heterogeneity of genetic risk of multiple cancers by cancer type by utilizing novel statistical techniques for GWAS.
Sonja I. Berndt, NCI/DCEG
Kai Yu, NCI/DCEG
Lindsay M. Morton, NCI/DCEG
Meredith Yeager, NCI/CGR
Nilanjan Chatterjee, Johns Hopkins University
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A Linear Relationship between the Number of Cancers among First-Degree Relatives and the Risk of Multiple Primary Cancers.
He S , Barry KH , Mitchell BD , Chen S , Zhang Y , Beane Freeman LE , Berndt SI
Cancer Prev Res (Phila). 2024 Jun 28; Pages OF1-OF7 PUBMED