A genome-wide survival analysis of non-small cell lung cancers

Principal Investigator

Name
David Christiani

Degrees
MPH, MS, MD

Institution
Harvard University

Position Title
Professor

Email
dchris@hsph.harvard.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-208

Initial CDAS Request Approval
Apr 26, 2016

Title
A genome-wide survival analysis of non-small cell lung cancers

Summary
Lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths all over the world. Individual variation in genetic background may influence treatments and clinical outcomes of NSCLC patients. To better understand the effects of molecular biomarkers, we are going to conduct a genome-wide analysis to investigate the prognostic implications of genetic variants in NSCLC patients. We will perform single nucleotide polymorphism (SNP)-based and gene-based analysis using multivariate logistic regression model and multivariate logistic kernel machine, respectively. Meta-analysis will be adopted to improve statistical power by integrating samples from Harvard School of Public Health (HSPH) and PLCO.

Aims

To identify NSCLC survival risk associated SNPs or genes.

Collaborators

Ruyang Zhang, Harvard School of Public Health
Yongyue Wei, Harvard School of Public Health
Zhaoxi Wang, Harvard School of Public Health

Related Publications

• Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
  Yang S, Tang D, Zhao YC, Liu H, Luo S, Stinchcombe TE, Glass C, Su L, Shen S, Christiani DC, Wang Q, Wei Q
  Int. J. Cancer. 2020 Jul 15; Volume 147 (Issue 2): Pages 392-403 PUBMED
• Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.
  Qian D, Liu H, Zhao L, Wang X, Luo S, Moorman PG, Patz EF, Su L, Shen S, Christiani DC, Wei Q
  Transl Lung Cancer Res. 2020 Jun; Volume 9 (Issue 3): Pages 575-586 PUBMED
• Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial.
  Guo Y, Feng Y, Liu H, Luo S, Clarke JW, Moorman PG, Su L, Shen S, Christiani DC, Wei Q
  Mol Carcinog. 2019 Jul; Volume 58 (Issue 7): Pages 1094-1104 PUBMED
• Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
  Xu Y, Liu H, Liu S, Wang Y, Xie J, Stinchcombe TE, Su L, Zhang R, Christiani DC, Li W, Wei Q
  Int. J. Cancer. 2018 Jul PUBMED
• Genetic variants in ABCG1 are associated with survival of nonsmall-cell lung cancer patients.
  Wang Y, Liu H, Ready NE, Su L, Wei Y, Christiani DC, Wei Q
  Int. J. Cancer. 2016 Jun; Volume 138 (Issue 11): Pages 2592-601 PUBMED