A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.
Authors
Kuznetsov IB, McDuffie M, Moslehi R
Affiliations
- Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA. ikuznetsov@albany.edu
Abstract
N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.
AVAILABILITY: Freely available at http://nat2pred.rit.albany.edu.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Publication Details
PubMed ID
19261719
Publication
Bioinformatics. 2009 May; Volume 25 (Issue 9): Pages 1185-6