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NLST

The National Lung Screening Trial (NLST) was a randomized controlled trial conducted by the Lung Screening Study group (LSS) and the American College of Radiology Imaging Network (ACRIN) to determine whether screening for lung cancer with low-dose helical computed tomography (CT) reduces mortality from lung cancer in high-risk individuals relative to screening with chest radiography. Approximately 54,000 participants were enrolled between August 2002 and April 2004. Data collection has ended, and information is complete through December 31, 2009. NLST has the ClinicalTrials.gov registration number NCT00047385.

This website enables users to request NLST datasets, CT or pathology images, and Tissue Microarrays, learn about NLST, and search a database of research projects and publications. To obtain NLST datasets, CT images, and/or pathology images, submit a request through this website. The datasets are comprehensive; they include data on participant characteristics, screening exam results, diagnostic procedures, lung cancer, and mortality. Images from over 75,000 CT screening exams are available. Over 1,200 pathology images from a subset of NLST lung cancer patients (~500 of over 2,000 patients) may be made available. The ECOG-ACRIN website should be referenced to request unique data elements, x-ray images, or biospecimens collected only by ACRIN (further detail below).

This website is organized into several sections as follows.

NLST Resources from Other Web Sites

As referenced above, please note that NLST was administered by two separate groups: the Lung Screening Study group (LSS), and the American College of Radiology Imaging Network (ACRIN).

Images

  • (For CT and Pathology images, submit a request through this website. See Images page for more information.)
  • For x-ray images, select "Contact Us" at the ECOG-ACRIN website. By completing the form and choosing the subject of "Data Sharing", the pertinent ECOG-ACRIN staff members (including the Data Sharing Administrator at Biostatistics Center) will be notified of the request and will respond to the investigator within 48 working hours.

Biospecimens

  • A tissue resource (microarrays and dna cores) for lung cancer was created from tissue resected as part of lung cancer diagnosis and treatment. These specimens are available through the PLCO Etiologic and Early Marker Studies Program (EEMS). More information about the materials available and protocol of collection is available in the Biospecimens Collected section, and to learn about the approval process for acquisition see the PLCO EEMS Application page section.
  • ACRIN biospecimens, including blood, urine, and sputum collected at the screening exams, and tissue from participants diagnosed with lung cancer may be requested by selecting "Contact Us" at the ECOG-ACRIN website. By completing the form and choosing the subject of "Data Sharing", the pertinent ECOG-ACRIN staff members (including the Data Sharing Administrator at Biostatistics Center) will be notified of the request and will respond to the investigator within 48 working hours.

ACRIN-Only Data

  • Availability of additional ACRIN data can be requested by selecting "Contact Us" at the ECOG-ACRIN website. By completing the form and choosing the subject of "Data Sharing", the pertinent ECOG-ACRIN staff members (including the Data Sharing Administrator at Biostatistics Center) will be notified of the request and will respond to the investigator within 48 working hours.