The Lung Screening Study (LSS) was a pilot study designed to assess the feasibility of conducting a large scale randomized controlled trial (RCT) of low radiation dose spiral computed tomography (LDCT) versus chest X-ray (CXR) for lung cancer screening. During the fall of 2000, six PLCO screening centers recruited a total of 3,318 heavy or long-term smokers who were not participants in the PLCO trial and randomized them to receive either a screening LDCT scan (1,660 participants) or screening posteroanterior view chest radiograph (CXR) [1,658 participants].
The results of the LSS demonstrated convincingly the feasibility of an RCT of LDCT scanning in the United States.
Study Years: 2000-2002
Randomized trial with two arms:
- Arm I: Screening LDCT scan
- Arm II: Screening posteroanterior view chest radiograph (CXR)
- Ages Eligible for Study: 55-74
- Sexes Eligible for Study: Male and Female
- Not enrolled in PLCO trial
- Current/Former Heavy smokers
- 1,660 in LDCT Arm
- 1,658 in CXR Arm
Total Study Population Demographics (3,318 Randomized and Eligible People):
The Schema is a timeline of the study. It indicates start/end points, visits expected, major testing to be done, and any other information that is crucial to understanding how the study was completed.
LSS Feasibility study protocol: The study randomized participants into two arms, one receiving spiral CT, the other chest x-ray. Participants underwent two years of screening with an annual study update at the second screening year. Screen results in each year were examined for adverse events due to screening and early lung cancer detection. Adverse events of treatment were subsequently recorded.