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Principal Investigator
Name
Ann Hsing
Institution
NCI, DCEG, HREB
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2006-0147
Initial CDAS Request Approval
Jul 1, 2006
Title
Prostate Cancer Dietary factors - Glycemic Factors/Inflammatory Factors
Summary
Obesity and insulin resistance have been linked to an increased risk of aggressive prostate cancer. Dietary carbohydrates have different glycemic and insulinemic potentials depending on type and amount of carbohydrate consumed. To determine the relationships between glycemic index and prostate cancer risk, we analyzed glycemic index and load (amount consumed) in relation to prostate cancer risk among 29,356 men ages 55 to 74 who were initially screened for prostate cancer from 1993 to 2001 in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial. Men were followed from their first screening exam until September 30, 2002, during which 1,338 cases of prostate cancer were identified. Dietary data from the PLCO food frequency questionnaire were used to compile glycemic index and load for each subjects and used for analysis.
Aims

To determine whether use of NSAIDs is associated with reduced risk of prostate cancer in a large prospective study.