Applying LungRads to NLST

Principal Investigator

Name
Paul Pinsky

Institution
NCI

Position Title
Acting Chief, Early Detection Branch

Email
pp4f@nih.gov

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-79

Initial CDAS Request Approval
Jun 24, 2014

Title
Applying LungRads to NLST

Summary
LungRADs is a scoring system for low-dose CT screening developed by the American College of Radiology (ACR) that is analogous to BIRADS for mammography. We are interested in the LungRads classifications when it is applied in NLST.

Aims

1. To determine the distribution of LungRads scores for subjects with and without cancer in NLST.
2. To assess sensitivity, specificity and PPV using LungRads applied to NLST, using the LungRads cutoff of 3 to define a positive screen.
3. To ascertain the reasons for false negative screens using LungRads.

Collaborators

Ella Kazerooni, Univ of Michigan

Related Publications

• Performance of Lung-RADS in the National Lung Screening Trial: a retrospective assessment.
  Pinsky PF, Gierada DS, Black W, Munden R, Nath H, Aberle D, Kazerooni E
  Ann. Intern. Med. 2015 Feb; Volume [Epub ahead of print]: Pages [Epub ahead of print] PUBMED