Estimating the lung cancer mortality benefit of screening within lung cancer risk strata in the National Lung Screening Trial (Original Project: 201204-0017)

Principal Investigator

Name
Hormuzd Katki

Degrees
PhD

Institution
American Cancer Society

Position Title
Scientific Vice President

Email
hormuzd.katki@cancer.org

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-1507

Initial CDAS Request Approval
Apr 28, 2026

Title
Estimating the lung cancer mortality benefit of screening within lung cancer risk strata in the National Lung Screening Trial (Original Project: 201204-0017)

Summary
We propose to categorize people by their risk of lung cancer based on smoking and other information relevant to lung cancer risk. We want to see if the lung cancer mortality benefit varies by strata of lung cancer risk. We will examine how the effects of screening varies according to different factors. We will examine how screening affects cancer staging, including finer T N M staging. We will examine how treatments affect survival after cancer diagnosis. We will stratify the data by different factors to calculate rates of incidence and mortality. We will fit generalized linear models and fit Cox models and calculate life years gained from screening.

Aims

* Calculate individualized lung cancer risk, competing mortality risk, and all cause mortality risk.
* Calculate the benefits of screening, primarily as the reduction in lung cancer mortality risk using Poisson models and Cox models
* Examine how the effects of screening varies according to different factors
* Examine how cancer staging, including finer T N M staging, is affected by screening
* Examine how treatments affect survival after cancer diagnosis
* Examine how screening test findings, both Lung-RADS scores and radiomics features of each screen, affect risk and benefit from screening
* Calculate life years gained from screening with the trial and projected to lifetimes

Collaborators

Li Cheung NCI
Hormuzd Katki American Cancer Society
Rebecca Landy American Cancer Society