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Long term lung cancer risk of non-calcified nodules

Principal Investigator
Name
Paul Pinsky
Degrees
PhD
Institution
NCI
Position Title
Researcher
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
NLST-30
Initial CDAS Request Approval
Aug 2, 2013
Title
Long term lung cancer risk of non-calcified nodules
Summary
In chemoprevention studies, surrogate endpoints of effect are needed to make studies more feasible. For lung cancer, some studies have used number and size of lung nodules detected on CT as such a surrogate. However, it is not known if such nodules are actually cancer precursors, and thus if they are a valid surrogate.
This studies aims to assess the long term lung cancer risk of such nodules. If they are associated with long term increased risk, after allowing for any current actual cancers to be diagnosed, this provides some evidence that they are a valid surrogate.
Aims

Specific aims:
1: W will analyze the risk of lung cancer associated with lung nodules, after allowing sufficient time (around 3 years) for any actual current cancer to be diagnosed. We will analyze outcomes by lung (left/right) and lung lobe; thus we will see if a nodule in a given lung (lobe) is associated with cancer (starting 3 years after the screen that noted the nodule) in that same lung (lobe).
2. To analyze the above risk by nodule size, stability and type.

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