NLST lung cancer distribution during screening and post-screening
Principal Investigator
Name
Rowena Yip
Degrees
PhD, MPH
Institution
Icahn School of Medicine at Mount Sinai
Position Title
Biostatistician
Email
About this CDAS Project
Study
NLST
(Learn more about this study)
Project ID
NLST-20
Initial CDAS Request Approval
Jun 6, 2013
Title
NLST lung cancer distribution during screening and post-screening
Summary
We are interested in determining type of lung cancers diagnosed in different nodule types and in understanding their distribution according to nodule size and other imaging and clinical risk factors (e.g., age, smoking history). To understand lung cancers survival and deaths diagnosed in both arms of the trial by nodule type, nodule size, cell-type, workup and stage, by age and smoking history.
Aims
1. Frequency of nodule as a function of associated risk factors
2. Frequency of lung cancer as a function of associated risk factors
3. Stage distribution given diagnosis of lung cancer
4. Frequency of survival given size, stage, and cell-type distribution
Collaborators
1) David Yankelevitz, Tisch Cancer Center, Mount Sinai School of Medicine
2) Claudia Henschke, Tisch Cancer Center, Mount Sinai School of Medicine
3) Paolo Boffetta, Institute for Translational Epidemiology, Mount Sinai School of Medicine
Related Publications
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Lung Cancers Manifesting as Part-Solid Nodules in the National Lung Screening Trial.
Yip R, Henschke CI, Xu DM, Li K, Jirapatnakul A, Yankelevitz DF
AJR Am J Roentgenol. 2017 May; Volume 208 (Issue 5): Pages 1011-1021 PUBMED -
Lung Cancer Deaths in the National Lung Screening Trial Attributed to Nonsolid Nodules.
Yip R, Yankelevitz DF, Hu M, Li K, Xu DM, Jirapatnakul A, Henschke CI
Radiology. 2016 Jul; Pages 152333 PUBMED -
CT screening for lung cancer: alternative definitions of positive test result based on the national lung screening trial and international early lung cancer action program databases.
Yip R, Henschke CI, Yankelevitz DF, Smith JP
Radiology. 2014 Nov; Volume 273 (Issue 2): Pages 591-6 PUBMED -
The impact of the regimen of screening on lung cancer cure: a comparison of I-ELCAP and NLST.
Yip R, Henschke CI, Yankelevitz DF, Boffetta P, Smith JP, International Early Lung Cancer Investigators
Eur. J. Cancer Prev. 2014 Aug PUBMED