NLST lung cancer distribution during screening and post-screening

Principal Investigator

Name
Rowena Yip

Degrees
PhD, MPH

Institution
Icahn School of Medicine at Mount Sinai

Position Title
Biostatistician

Email
rowena.yip@mountsinai.org

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-20

Initial CDAS Request Approval
Jun 6, 2013

Title
NLST lung cancer distribution during screening and post-screening

Summary
We are interested in determining type of lung cancers diagnosed in different nodule types and in understanding their distribution according to nodule size and other imaging and clinical risk factors (e.g., age, smoking history). To understand lung cancers survival and deaths diagnosed in both arms of the trial by nodule type, nodule size, cell-type, workup and stage, by age and smoking history.

Aims

1. Frequency of nodule as a function of associated risk factors
2. Frequency of lung cancer as a function of associated risk factors
3. Stage distribution given diagnosis of lung cancer
4. Frequency of survival given size, stage, and cell-type distribution

Collaborators

1) David Yankelevitz, Tisch Cancer Center, Mount Sinai School of Medicine
2) Claudia Henschke, Tisch Cancer Center, Mount Sinai School of Medicine
3) Paolo Boffetta, Institute for Translational Epidemiology, Mount Sinai School of Medicine

Related Publications

• Lung Cancers Manifesting as Part-Solid Nodules in the National Lung Screening Trial.
  Yip R, Henschke CI, Xu DM, Li K, Jirapatnakul A, Yankelevitz DF
  AJR Am J Roentgenol. 2017 May; Volume 208 (Issue 5): Pages 1011-1021 PUBMED
• Lung Cancer Deaths in the National Lung Screening Trial Attributed to Nonsolid Nodules.
  Yip R, Yankelevitz DF, Hu M, Li K, Xu DM, Jirapatnakul A, Henschke CI
  Radiology. 2016 Jul; Pages 152333 PUBMED
• CT screening for lung cancer: alternative definitions of positive test result based on the national lung screening trial and international early lung cancer action program databases.
  Yip R, Henschke CI, Yankelevitz DF, Smith JP
  Radiology. 2014 Nov; Volume 273 (Issue 2): Pages 591-6 PUBMED
• The impact of the regimen of screening on lung cancer cure: a comparison of I-ELCAP and NLST.
  Yip R, Henschke CI, Yankelevitz DF, Boffetta P, Smith JP, International Early Lung Cancer Investigators
  Eur. J. Cancer Prev. 2014 Aug PUBMED