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Male Pattern hair loss and Risk of Stroke Mortality: An Exploration Based on the PLCO Cohort Study

Principal Investigator
Name
Hui Tang
Degrees
Doctor
Institution
Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital
Position Title
Director
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1825
Initial CDAS Request Approval
Feb 12, 2025
Title
Male Pattern hair loss and Risk of Stroke Mortality: An Exploration Based on the PLCO Cohort Study
Summary
Male pattern baldness is a common condition in men, and its prevalence significantly increases with age. Stroke is one of the leading causes of death and disability worldwide. Understanding the risk factors for stroke, along with early assessment and intervention, is essential for reducing the incidence and mortality rates associated with this condition. Recent studies suggest a potential link between male pattern baldness and an increased risk of cardiovascular disease, which is a well-known major risk factor for stroke [1]. Furthermore, studies have indicated that alopecia areata also increases the risk of stroke [2]. However, research examining the association between male pattern baldness and the risk of stroke mortality is limited, particularly due to a lack of robust evidence from large-scale population-based cohort studies. Investigating this relationship using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort is of significant public health importance.

Reference
[1] Schooling CM, Luo S, Au Yeung SL, et al. Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation. Int J Cardiol. 2018;267:171-176.
[2] Kang JH, Lin HC, Kao S, Tsai MC, Chung SD. Alopecia Areata Increases the Risk of Stroke: a 3-year Follow-Up Study. Sci Rep. 2015;5:11718.
Aims

This project aims to investigate the association between male pattern baldness and the risk of stroke mortality using data from the prospective Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort. This project aims to investigate the association between male pattern baldness and the risk of stroke mortality using data from the prospective Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort. We will employ survival analysis methods, specifically competing risk models, to analyze the association between baldness and stroke mortality risk, adjusting for potential confounding factors such as age, race, smoking status, BMI, history of hypertension, and history of diabetes mellitus.

Collaborators

Chuan Shao, Department of Neurosurgery, Chongqing General Hospital, Chongqing University, Chongqing, China;
Lihua LI, Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital;
Heng Dong, Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital;
Chen Chen, Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College;
Mingjun Dai, Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College;
Zhou Li, Beijing Anzhen Nanchong Hospital of Capital Medica University & Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College.