Association Between Age and Lung Cancer: Exploring the Mediating Effects of Lobar Radiomics
Principal Investigator
Name
Lei Shi
Degrees
M.D.
Institution
Radiology Department of Zhejiang Cancer Hospital
Position Title
Chief Physician and Head of Radiology Department
Email
About this CDAS Project
Study
NLST
(Learn more about this study)
Project ID
NLST-1371
Initial CDAS Request Approval
Dec 16, 2024
Title
Association Between Age and Lung Cancer: Exploring the Mediating Effects of Lobar Radiomics
Summary
This project explores the relationship between aging and lung cancer through the mediating role of lobar imaging features. Aging leads to structural and functional changes in the lungs, which may contribute to the development of lung cancer. By focusing on these changes, this study aims to uncover how age-related alterations in lobar radiomics features influence lung cancer risk.
The study will segment lung images into 5 lobes and analyze radiomics features to identify those associated with aging and lung cancer risk. Mediation analysis will explore whether these features mediate the link between aging and lung cancer. The NLST dataset will be used for external validation to ensure the findings are robust and generalizable.
This research provides critical insights into the biological mechanisms of lung cancer in the aging population and highlights the potential of imaging features in early detection and risk assessment.
The study will segment lung images into 5 lobes and analyze radiomics features to identify those associated with aging and lung cancer risk. Mediation analysis will explore whether these features mediate the link between aging and lung cancer. The NLST dataset will be used for external validation to ensure the findings are robust and generalizable.
This research provides critical insights into the biological mechanisms of lung cancer in the aging population and highlights the potential of imaging features in early detection and risk assessment.
Aims
1. Identify age-related lobar imaging features and their associations with lung cancer.
2. Explore the mediating role of these features in the relationship between aging and lung cancer.
Collaborators
Lei Shi, Department of Radiology, Zhejiang Cancer Hospital
Kun Chen, Department of Radiology, Zhejiang Cancer Hospital
Chao Huang, Department of Radiology, Zhejiang Cancer Hospital
Yuwei Li, Department of Radiology, Zhejiang Cancer Hospital