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Body fat distribution and risk of colorectal cancer in the PLCO cohort

Principal Investigator
Name
Shun Zhang
Degrees
M.D., Ph.D
Institution
Shanghai East Hospital, School of Medicine, Tongji University
Position Title
Dr
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1736
Initial CDAS Request Approval
Nov 7, 2024
Title
Body fat distribution and risk of colorectal cancer in the PLCO cohort
Summary
Colorectal cancer (CRC) contributes to the global burden of cancer incidence, and despite declining rates of CRC in some developed countries, CRC incidence remains high. As revealed by epidemiological evidence, excess body fat (i.e., being overweight/ obese) is a potentially modifiable lifestyle factor related to CRC. There are several methods to evaluate excess body fat, such as the body mass index (BMI), waist circumference, and waist-to-hip ratio, among others, although BMI is traditionally and widely used as a measurement for easy operation in large epidemiological studies. Recently, new indices for fat distribution have been developed and applied to predict health outcomes. A body shape index (ABSI) and body roundness index (BRI) stand out among these alternative indices for their unique advantages: ABSI reflects the extra effect of abdominal obesity and was independent of BMI by design; BRI was identified as a good predictor of metabolic syndrome. Nonetheless, no formal study has evaluated the association between ABSI and BRI with colorectal cancer risk up to now.
Based on the PLCO cohort, a large population-based, prospective cohort study , the current study aimed to characterize the dose- response relationship between fat distribution measurements and the incidence of primary colorectal cancer.
Aims

Based on the PLCO cohort, the large population-based, prospective cohort study , the present study examined the associations between fat distribution measurements and the risk of colorectal cancer, with four traditional anthropometrics (Waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio) and two newly developed indices (A body shape index and body roundness index) as exposure variables. We also want to explore the association of CRC risk with age- specific BMI, average BMI, body weight changes, and life-course body roundness index trajectories.

Collaborators

Xiao-hua Jiang, Shanghai East Hospital, School of Medicine, Tongji University
Ren-hao Hu, Shanghai East Hospital, School of Medicine, Tongji University
Jia-xing Dong, Shanghai East Hospital, School of Medicine, Tongji University
Ke-hui Zhang, Shanghai East Hospital, School of Medicine, Tongji University
Ming-yi Yuan, Shanghai East Hospital, School of Medicine, Tongji University