Yi Xiao

Ph.D.

The Second Affiliated Hospital of Chongqing Medical University

student

PLCO (Learn more about this study)

PLCO-1733

Nov 7, 2024

The correlation between Fat Quality Index and the risk of upper gastrointestinal cancer in the American population: a prospective cohort study

The Fat Quality Index (FQI), as an integrative metric, has become a widely adopted tool for assessing dietary quality, especially in elucidating the relationship between fat intake and health outcomes[1]. By quantifying the structural composition of dietary fats within individuals, FQI sheds light on the rationality of population dietary habits and their level of nutritional balance. In recent years, FQI has increasingly been incorporated into studies examining the potential impact of diverse dietary patterns on chronic diseases—such as cardiovascular conditions, diabetes, and various cancers—thus providing a novel scientific basis for dietary intervention strategies aimed at mitigating these ailments[2.3]. However, despite significant advances in chronic disease research involving FQI, investigations into its association with the risk of upper gastrointestinal malignancies, such as esophageal and gastric cancers, remain relatively limited. Therefore, this paper seeks to examine the relationship between FQI and the incidence of upper gastrointestinal malignancies within the context of large, prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial cohort, with a further focus on analyzing its subgroup-specific influences.

Reference:
1. Schwingshackl, L., Zähringer, J., Beyerbach, J., Werner, S. S., Heseker, H., Koletzko, B., & Meerpohl, J. J. (2021). Total Dietary Fat Intake, Fat Quality, and Health Outcomes: A Scoping Review of Systematic Reviews of Prospective Studies. Annals of nutrition & metabolism, 77(1), 4–15. https://doi.org/10.1159/000515058
2. Yao, X., Xu, X., Wang, S., & Xia, D. (2021). Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study. Frontiers in nutrition, 8, 701430. https://doi.org/10.3389/fnut.2021.701430
3. Julibert, A., Bibiloni, M. D. M., Bouzas, C., Martínez-González, M. Á., Salas-Salvadó, J., Corella, D., Zomeño, M. D., Romaguera, D., Vioque, J., Alonso-Gómez, Á. M., Wärnberg, J., Martínez, J. A., Serra-Majem, L., Estruch, R., Tinahones, F. J., Lapetra, J., Pintó, X., Lopez-Miranda, J., García-Molina, L., Gaforio, J. J., … Predimed-Plus Investigators (2019). Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk. Nutrients, 11(7), 1493. https://doi.org/10.3390/nu11071493