Associations between sulfur microbial diet and mortality from all causes, cardiovascular disease and cancer: A prospective cohort study
Principal Investigator
Name
Lifu Lei
Degrees
M.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University
Position Title
Registered Dietitian
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1653
Initial CDAS Request Approval
Aug 28, 2024
Title
Associations between sulfur microbial diet and mortality from all causes, cardiovascular disease and cancer: A prospective cohort study
Summary
The gut microbiota is closely related to several chronic diseases, such as cardiovascular disease and cancer. Cardiovascular disease (CVD), mainly ischemic heart disease (IHD) and stroke, is the leading cause of death worldwide and a leading cause of disability. The global prevalence of CVD nearly doubled from 1993 to 2019 and is projected to continue to increase through 2024 [1].
Recently, the Health Professionals Follow-up Study (HPFS) has derived a special pattern consisting of particular food groups associated with the increased abundance of sulfur-metabolizing microbes [2]. Sulfur-metabolizing bacteria is known to metabolize dietary sulfur to hydrogen sulfide (H2S) that influences gut permeability and inflammation, which has been related to the occurrence of colon cancer, obesity, and non-alcoholic fatty liver disease in recent years [3-5]. However, to the best of our knowledge, no epidemiological studies have evaluated the potential association of sulfur microbial diet with the risk of death from all causes, cardiovascular disease, and cancer. To address these knowledge gaps, we conducted this study to explore the potential association between sulfur microbial diet and mortality from all causes, cardiovascular disease and cancer, in a large US population from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort.
References
1. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1223-1249.
2. Nguyen LH, Ma W, Wang DD, et al. Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020;158(5):1313-1325.
3. Liu X, Wan X, Zhang L, et al. The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study. Clin Nutr. 2023;42(5):764-772.
4 Liu Z, Huang H, Ruan J, Wang Z, Xu C. The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene-diet study from the UK Biobank. Am J Clin Nutr. 2024;119(2):417-424.
5. Xiao Y, He H, Xiang L, et al. Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults. Front Nutr. 2023;10:1167372.
Recently, the Health Professionals Follow-up Study (HPFS) has derived a special pattern consisting of particular food groups associated with the increased abundance of sulfur-metabolizing microbes [2]. Sulfur-metabolizing bacteria is known to metabolize dietary sulfur to hydrogen sulfide (H2S) that influences gut permeability and inflammation, which has been related to the occurrence of colon cancer, obesity, and non-alcoholic fatty liver disease in recent years [3-5]. However, to the best of our knowledge, no epidemiological studies have evaluated the potential association of sulfur microbial diet with the risk of death from all causes, cardiovascular disease, and cancer. To address these knowledge gaps, we conducted this study to explore the potential association between sulfur microbial diet and mortality from all causes, cardiovascular disease and cancer, in a large US population from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort.
References
1. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1223-1249.
2. Nguyen LH, Ma W, Wang DD, et al. Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020;158(5):1313-1325.
3. Liu X, Wan X, Zhang L, et al. The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study. Clin Nutr. 2023;42(5):764-772.
4 Liu Z, Huang H, Ruan J, Wang Z, Xu C. The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene-diet study from the UK Biobank. Am J Clin Nutr. 2024;119(2):417-424.
5. Xiao Y, He H, Xiang L, et al. Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults. Front Nutr. 2023;10:1167372.
Aims
Our purpose is to explore the association between sulfur microbial diet and mortality from all causes, cardiovascular disease, and cancer in the US population using the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort. Additionally, we aim to examine the potential dose-response relationship between the sulfur microbial diet score and mortality from all causes, cardiovascular disease, and cancer.
Collaborators
Qin Zhou, The Second Affiliated Hospital of Chongqing Medical University
Yushi Chen, The Second Affiliated Hospital of Chongqing Medical University