Cancer risk after radiation exposure from low dose lung cancer screening (NCI Only version of NLST-1127)

Principal Investigator

Name
Choonsik Lee

Degrees
PhD

Institution
National Cancer Institute

Position Title
Senior Investigator

Email
leechoonsik@mail.nih.gov

About this CDAS Project

Study
NLST (Learn more about this study)

Project ID
NLST-1307

Initial CDAS Request Approval
Aug 19, 2024

Title
Cancer risk after radiation exposure from low dose lung cancer screening (NCI Only version of NLST-1127)

Summary
Lung cancer screening using a low dose chest CT scans has proven to be effective in early detection of lung cancer and reduced mortality. However, a lingering concern is the radiation-related cancer risk associated with these low dose chest CT scans. The broader implications regarding cancer incidence due to radiation exposure remain inadequately explored.

Aims

This study aims to assess the non-lung cancer risk in lung cancer screening participants following exposure to low dose chest CT scans. The primary outcome is the incidence rates of cancers, excluding lung cancer, in individuals who have been exposed to a CT scan more than one year prior to any cancer diagnosis. This will be compared to the non-lung cancer incidence rates in a control group comprising individuals who underwent a chest X-ray screening.

Collaborators

Soon Ho Yoon, Radiology, Seoul National University Hospital, Seoul, Republic of Korea
Hyunsook Hong, Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea