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Principal Investigator
Name
Radoslav Goldman
Institution
Georgetown University
Email
About this CDAS Project
Study
NLST (Learn more about this study)
Project ID
2004-90020
Initial CDAS Request Approval
Jan 9, 2004
Title
Recruitment of Control Participants for a Study of Head and Neck Cancer
Summary
This study aims to recruit NLST subjects to make up part of the control group in a case-control study of head and neck cancer. Blood, urine and buccal cells will be collected, and subjects will fill out a questionnaire. The study will measure mutagen sensitivity, examine polymorphisms in several DNA repair genes, and evaluate the possibility of identifying a diagnostic pattern for early diagnosis by serum protein profiling.
Aims

This study develops an infrastructure to study HN cancer risk factors and to identify markers of HN cancer for early detection and optimized intervention. The specific aims and hypotheses of this project are the following: 1. Recruit HN cancer cases and controls to provide an epidemiological profile, blood, urine, buccal cells, and tumor tissue (when available). This will establish a data and tissue repository. 2. Utilize the repository to study low penetrance genes, investigate gene-environment interactions and establish genotype-phenotype relationships involving response to DNA damage, in order to identify or validate the use of intermediate biomarkers of cancer risk. H2a High mutagen sensitivity/comet assay increase the risk of HN cancer. H2d At risk variants of XRCC1, APE1, XPD, and XRCC3 DNA repair genes increase HN cancer risk. 3. To identify diagnostic signature of peptides/proteins in the serum of cancer patients. H3a Sera of patients with HN cancer contain a set of proteins/peptides (diagnostic signature) that identifies the disease with high sensitivity and specificity.

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