Recruitment of Control Participants for a Study of Head and Neck Cancer
This study develops an infrastructure to study HN cancer risk factors and to identify markers of HN cancer for early detection and optimized intervention. The specific aims and hypotheses of this project are the following: 1. Recruit HN cancer cases and controls to provide an epidemiological profile, blood, urine, buccal cells, and tumor tissue (when available). This will establish a data and tissue repository. 2. Utilize the repository to study low penetrance genes, investigate gene-environment interactions and establish genotype-phenotype relationships involving response to DNA damage, in order to identify or validate the use of intermediate biomarkers of cancer risk. H2a High mutagen sensitivity/comet assay increase the risk of HN cancer. H2d At risk variants of XRCC1, APE1, XPD, and XRCC3 DNA repair genes increase HN cancer risk. 3. To identify diagnostic signature of peptides/proteins in the serum of cancer patients. H3a Sera of patients with HN cancer contain a set of proteins/peptides (diagnostic signature) that identifies the disease with high sensitivity and specificity.
Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assay.
Saha DT, Davidson BJ, Wang A, Pollock AJ, Orden RA, Goldman R
Mutat. Res. 2008 Jan; Volume 650 (Issue 1): Pages 55-62 PUBMED